Vermin, Not Politician Variety, Altho They Skew Closely: US Cities With the Most Rats

Ket Takeaways

• New York City, Los Angeles, and Philadelphia rank as the city with the most rats and mice due to abundant food waste, shelter, and dense populations.
• Spotting small droppings, chewed wires, or nesting materials around your home is often the first sign of an active mouse or rat infestation.
• Proper waste management, securely storing food, and sealing structural entry points can help prevent mice and rats from accessing your living spaces.
• Professional rodent control services can help address active infestations and help protect your property from returning pests.

Rats and mice are a common problem in U.S. cities, where food waste, sanitation practices, and abundant shelter can create ideal conditions for rodents to thrive. These pests can damage property and pose public health concerns, making effective rodent control important for homeowners and businesses.

So, what city has the most rats and mice? We ranked the 50 cities with the most rats and mice in the U.S., based on where homeowners needed rodent services most often, according to our Rentokil-owned Terminix branch data from 2025. New York continues to lead the list as the top city for rodent activity, followed by Los Angeles, Philadelphia, San Francisco, and Houston. Keep reading to see if your city made the list!